Our main goal is to understand how the brain supports consciousness and what goes wrong for patients to become entirely unaware after severe brain injury. We use techniques such as MRI (structural and functional), tDCS, and behavioural approaches in both healthy volunteers and patients with a disorder of consciousness to test hypothesis about the role of different brain structures in the clinical deficits they present. Our research is directly translated into the development of diagnostic and prognostic biomarkers to be used in clinical settings, as well as the development of novel treatment approaches.